VA continues to strive toward ending chronic homelessness among Veterans. Co-occurring mental health and substance use disorders (COD) are one of the most common clinical problems among homeless Veterans – and threaten long-term housing stability and general substance use and mental health recovery. Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking-Veterans Edition (MISSION-Vet) is an evidence-based intervention developed within VA, with partial funding by HSR&D, and is included in the Substance Abuse and Mental Health Service Administration (SAMHSA) National Registry of Evidence-based Programs and Practices (NREPP) to address COD among homeless individuals.